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 2016

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133.Kracher, D., Scheiblbrandner, S., Felice, A.K.G., Breslmayr, E., Preims, M., Ludwicka, K., Haltrich, D., Eijsink, V.G.H., Ludwig, R. (2016)  Extracellular electron transfer systems fuel cellulose oxidative degradation, Science, 352 (6289), pp 1098-1101. DOI: 10.1126/science.aaf3165

132.Courtade, G., Wimmer, R., Røhr, Å.K., Preims, M., Felice, A.K.G., Dimarogona, M., Vaaje-Kolstad, G., Sørlie, M., Sandgren, M., Ludwig, R., Eijsink, V.G.H., Aachmann, F.L. (2016) Interactions of a fungal lytic polysaccharide monooxygenase with β-glucan substrates and cellobiose dehydrogenase, PNAS, 113 (21), pp. 5922-5928. DOI: 10.1073/pnas

131.Patel, I., Kracher, D., Ma, S., Garajova, S., Haon, M., Faulds, C.B., Berrin, J.-G., Ludwig, R., Record, E. (2016) Salt-responsive lytic polysaccharide monooxygenases from the mangrove fungus Pestalotiopsis sp. NCi6. Biotechnology for Biofuels, 9:108, DOI: 10.1186/s13068-016-0520-3

130.Andlar, M., Rezić, I., Oros, D., Kracher, D., Ludwig, R., Rezić, T., Šantek, B. (2016)  Optimization of enzymatic sugar beet hydrolysis in a horizontal rotating tubular bioreactor. Journal of Chemical Technology and Biotechnology, in press, DOI: 10.1002/jctb.5043

129.Pinyou, P., Ruff, A., Pöller, S., Ma, S., Ludwig, R., Schuhmann, W. (2016) Design of an Os Complex-Modified Hydrogel with Optimized Redox Potential for Biosensors and Biofuel Cells. Chemistry - A European Journal, 22 (15), pp. 5319-5326. DOI: 10.1002/chem.201504591

128.Schulz, C., Kittl, R., Ludwig, R., Gorton, L. (2016) Direct Electron Transfer from the FAD Cofactor of Cellobiose Dehydrogenase to Electrodes. ACS Catalysis, 6 (2), pp. 555-563. DOI: 10.1021/acscatal.5b01854

127.Tegl, G., Thallinger, B., Beer, B., Sygmund, C., Ludwig, R., Rollett, A., Nyanhongo, G.S., Guebitz, G.M. (2016) Antimicrobial Cellobiose Dehydrogenase-Chitosan Particles. ACS Applied Materials and Interfaces, 8 (1), pp. 967-973. DOI: 10.1021/acsami.5b10801

126.Couturier, M., Mathieu, Y., Li, A., Navarro, D., Drula, E., Haon, M., Grisel, S., Ludwig, R., Berrin, J.-G. (2016) Characterization of a new aryl-alcohol oxidase secreted by the phytopathogenic fungus Ustilago maydis. Applied Microbiology and Biotechnology, 100 (2), pp. 697-706. DOI: 10.1007/s00253-015-7021-3

 2015

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125.Bozorgzadeh, S., Hamidi, H., Ortiz, R., Ludwig, R., Gorton, L. (2015) Direct electron transfer of Phanerochaete chrysosporium cellobiose dehydrogenase at platinum and palladium nanoparticles decorated carbon nanotubes modified electrodes. Physical Chemistry Chemical Physics, 17 (37), pp. 24157-24165. DOI: 10.1039/c5cp03812j

124.Kracher, D., Zahma, K., Schulz, C., Sygmund, C., Gorton, L., Ludwig, R. (2015) Inter-domain electron transfer in cellobiose dehydrogenase: Modulation by pH and divalent cations. FEBS Journal, 282 (16), pp. 3136-3148. DOI: 10.1111/febs.13310

123.Pham, N.H., Hollmann, F., Kracher, D., Preims, M., Haltrich, D., Ludwig, R. (2015) Engineering an enzymatic regeneration system for NAD(P)H oxidation. Journal of Molecular Catalysis B: Enzymatic, 120, art. no. 3185, pp. 38-46. DOI: 10.1016/j.molcatb.2015.06.011

122.Tan, T.-C., Kracher, D., Gandini, R., Sygmund, C., Kittl, R., Haltrich, D., Ha¨llberg, B.M., Ludwig, R., Divne, C. (2015) Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation. Nature Communications, 6, art. no. 7542. DOI: 10.1038/ncomms8542

121.Lipovsky, A., Thallinger, B., Perelshtein, I., Ludwig, R., Sygmund, C., Nyanhongo, G.S., Guebitz, G.M., Gedanken, A. (2015) Ultrasound coating of polydimethylsiloxanes with antimicrobial enzymes. Journal of Materials Chemistry B, 3 (35), pp. 7014-7019. DOI: 10.1039/c5tb00671f

120.Molina-Espeja, P., Ma, S., Mate, D.M., Ludwig, R., Alcalde, M. (2015) Tandem-yeast expression system for engineering and producing unspecific peroxygenase. Enzyme and Microbial Technology, 73-74, pp. 29-33. DOI: 10.1016/j.enzmictec.2015.03.004

119.Kielb, P., Sezer, M., Katz, S., Lopez, F., Schulz, C., Gorton, L., Ludwig, R., Wollenberger, U., Zebger, I., Weidinger, I.M. (2015) Spectroscopic Observation of Calcium-Induced Reorientation of Cellobiose Dehydrogenase Immobilized on Electrodes and its Effect on Electrocatalytic Activity. ChemPhysChem, 16 (9), pp. 1960-1968. DOI: 10.1002/cphc.201500112

118.Megson, Z.A., Koerdt, A., Schuster, H., Ludwig, R., Janesch, B., Frey, A., Naylor, K., Wilson, I.B.H., Stafford, G.P., Messner, P., Schäffer, C. (2015) Characterization of an α-L-fucosidase from the periodontal pathogen Tannerella forsythia. Virulence, 6 (3), pp. 282-292. DOI: 10.1080/21505594.2015.1010982

117.Vasilchenko, L.G., Nyanhongo, G.S., Guebitz, G.M., Ludwig, R., Haltrich, D. (2015) Phenolic antioxidants and their role in quenching of reactive molecular species in the human skin injury. Lipid Technology, 27 (2), pp. 36-39. DOI: 10.1002/lite.201400078

116.Nugroho Prasetyo, E., Rodríguez, R.D., Lukesch, B., Weiss, S., Murkovic, M., Katsoyannos, E., Sygmund, C., Ludwig, R., Nyanhongo, G.S., Guebitz, G.M. (2015) Laccase–cellobiose dehydrogenase-catalyzed detoxification of phenolic-rich olive processing residues. International Journal of Environmental Science and Technology, 12 (4), pp. 1343-1352. DOI: 10.1007/s13762-014-0526-y

115.Osipov, E.M., Polyakov, K.M., Tikhonova, T.V., Kittl, R., Dorovatovskii, P.V., Shleev, S.V., Popov, V.O., Ludwig, R. (2015) Incorporation of copper ions into crystals of T2 copper-depleted laccase from Botrytis aclada. Acta Crystallographica Section:F Structural Biology Communications, 71, pp. 1465-1469. DOI: 10.1107/S2053230X1502052X

114.Kielb, P., Sezer, M., Katz, S., Lopez, F., Schulz, C., Gorton, L., Ludwig, R., Wollenberger, U., Zebger, I., Weidinger, I.M. (2015) Spectroscopic Observation of Calcium-Induced Reorientation of Cellobiose Dehydrogenase Immobilized on Electrodes and its Effect on Electrocatalytic Activity. ChemPhysChem, . Article in Press. DOI: 10.1002/cphc.201500112

113.Thallinger, B., Brandauer, M., Burger, P., Sygmund, C., Ludwig, R., Ivanova, K., Kun, J., Scaini, D., Burnet, M., Tzanov, T., Nyanhongo, G.S., Guebitz, G.M. (2015) Cellobiose dehydrogenase functionalized urinary catheter as novel antibiofilm system. Journal of Biomedical Materials Research - Part B Applied Biomaterials, . Article in Press. DOI: 10.1002/jbm.b.33491

112.Zolghadr, B., Gasselhuber, B., Windwarder, M., Pabst, M., Kracher, D., Kerndl, M., Zayni, S., Hofinger-Horvath, A., Ludwig, R., Haltrich, D., Oostenbrink, C., Obinger, C., Kosma, P., Messner, P., Schäffer, C. (2015) UDP-sulfoquinovose formation by Sulfolobus acidocaldarius. Extremophiles, 19 (2), pp. 451-467. DOI: 10.1007/s00792-015-0730-9

 2014

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111.Ortiz, R., Ludwig, R., Gorton, L. (2014) Highly Efficient Membraneless Glucose Bioanode Based on Corynascus thermophilus Cellobiose Dehydrogenase on Aryl Diazonium-Activated Single-Walled Carbon Nanotubes. ChemElectroChem, 1 (11), pp. 1948-1956. DOI: 10.1002/celc.201402197

110.Falk, M., Alcalde, M., Bartlett, P.N., De Lacey, A.L., Gorton, L., Gutierrez-Sanchez, C., Haddad, R., Kilburn, J., Leech, D., Ludwig, R., Magner, E., Mate, D.M., Conghaile, P.Ó., Ortiz, R., Pita, M., Pöller, S., Ruzgas, T., Salaj-Kosla, U., Schuhmann, W., Sebelius, F., Shao, M., Stoica, L., Sygmund, C., Tilly, J., Toscano, M.D., Vivekananthan, J., Wright, E., Shleev, S. (2014) Self-powered wireless carbohydrate/oxygen sensitive biodevice based on radio signal transmission. PLoS ONE, 9 (10), art. no. e109104. DOI: 10.1371/journal.pone.0109104

109.Thallinger, B., Argirova, M., Lesseva, M., Ludwig, R., Sygmund, C., Schlick, A., Nyanhongo, G.S., Guebitz, G.M. (2014) Preventing microbial colonisation of catheters: Antimicrobial and antibiofilm activities of cellobiose dehydrogenase. International Journal of Antimicrobial Agents, 44 (5), pp. 402-408. DOI: 10.1016/j.ijantimicag.2014.06.016

108.Knöös, P., Schulz, C., Piculell, L., Ludwig, R., Gorton, L., Wahlgren, M. (2014) Quantifying the release of lactose from polymer matrix tablets with an amperometric biosensor utilizing cellobiose dehydrogenase. International Journal of Pharmaceutics, 468 (1-2), pp. 121-132. DOI: 10.1016/j.ijpharm.2014.03.060

107.Feifel, S.C., Kapp, A., Ludwig, R., Lisdat, F. (2014) Nanobiomolecular multiprotein clusters on electrodes for the formation of a switchable cascadic reaction scheme. Angew. Chem. 53:1-5. DOI: 10.1002/anie.201310437

106.Agger, J.W., Isaksen, T., Várnaia, A., Vidal-Melgosa, S.,  Willats, W.G.T., Ludwig, R., Horn, S.J., Eijsink, V.G.H., Westereng, B., (2014) Discovery of LPMO activity on hemicelluloses shows the importance of oxidative processes in plant cell wall degradation. Proc. Natl. Acad. Sci. 111: 6287-6292. DOI:10.1073/pnas.1323629111

105.Isaksen, T., Westereng, B., Aachmann, F.L. Agger, J.W., Kracher, D., Kittl, R., Ludwig, R., Haltrich, D., Eijsink, V.G.H,. Horn, S.J. (2014) A C4-oxidizing lytic polysaccharide monooxygenase cleaving both cellulose and cello-oligosaccharides. J. Biol. Chem. 289:2632-2642. DOI: 10.1074/jbc.M113.530196

104.Knöös, P., Schulz, C., Piculell, L., Ludwig, R., Gorton, L., Wahlgren, M. (2014) Quantifying the release of lactose from polymer matrix tablets with an amperometric biosensor utilizing cellobiose dehydrogenase. Int. J. Pharmaceut. 468:121-132. DOI: 10.1016/j.ijpharm.2014.03.060

103.Shao, M., Guschin, D.A., Kawah, Z., Beyl, Y., Stoica, L., Ludwig, R., Schuhmann, W., Chen, X. (2014) Cellobiose dehydrogenase entrapped within specifically designed Os-complex modified electrodeposition polymers as potential anodes for biofuel cells. Electrochim. Acta, 128:318-325. DOI: 10.1016/j.electacta.2013.11.019

102.Schulz, C., Ludwig, R., Gorton, L. (2014) Polyethyleneimine as a promoter layer for the immobilization of cellobiose dehydrogenase from Myriococcum thermophilum on graphite electrodes. Anal. Chem. 86:4256-4263. DOI: 10.1021/ac403957t

101.Kracher, D., Oros, D., Yao, W., Preims, M., Rezic, I., Haltrich, D., Rezic, T., Ludwig, R. (2014) Fungal secretomes enhance sugar beet pulp hydrolysis. Biotechnol. J. 9:483-492. DOI: 10.1002/biot.201300214

 2013

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100.Andoralov, V., Falk, M., Suyatin, D.B., Granmo, M., Sotres, J., Ludwig, R., Popov, V.O., Schouenborg, J., Blum, Z., Shleev, S. (2013) Biofuel cell based on microscale nanostructured electrodes with inductive coupling to rat brain neurons. Scientific Reports, 3:3270. DOI: 10.1038/srep03270

99.Mulla, D., Kracher, D., Ludwig, R., Nagy, G., Grandits, M., Holzer, W., Saber, Y., Gabra, N., Viernstein, H., Unger, F.M. (2013) Azido derivatives of cellobiose: oxidation at C1 with cellobiose dehydrogenase from Sclerotium rolfsii. Carbohydrate Res. 382:86-94. DOI: 10.1016/j.carres.2013.09.004

98.Zafar, M.N., Shao, M., Ludwig, R., Leech, D., Schuhmann, W., Gorton, L. (2013) Improving the current density and the coulombic efficiency by a cascade reaction of glucose oxidizing enzymes. ECS Transactions, 53:131-143.
DOI: 10.1149/05302.0131ecst

97.Kaswurm, V., van Hecke, W., Kulbe, K.D., Ludwig, R. (2013) Engineering of a bi-enzymatic reaction for efficient production of the ascorbic acid precursor 2-keto-l-gulonic acid. Biochem. Eng. J. 79:104-111. DOI:10.1016/j.bej.2013.07.010

96.Rezicó, T., Oros, D., Markovicó, I., Kracher, D., Ludwig, R., Šantek, B. (2013) Integrated hydrolyzation and fermentation of sugar beet pulp to bioethanol. J. Microbiol. Biotechnol. 23: 1244-1252. DOI:10.4014/jmb.1210.10013

95.Könst, P., Kara, S., Kochius, S., Holtmann, D., Arends, I.W.C.E., Ludwig, R., Hollmann, F. (2013) Expanding the scope of laccase-mediator systems. Chem. Cat. Chem. 5:3027-3032. DOI: 10.1002/cctc.201300205

94.Shao, M., Zafar, M.N., Falk, M., Ludwig, R., Sygmund, C., Peterbauer, C.K., Guschin, D.A., MacAodha, D., Conghaile, P.Ó., Leech, D., Toscano, M.D., Shleev, S., Schuhmann, W., Gorton, L. (2013) Optimization of a membraneless glucose/oxygen enzymatic fuel cell based on a bioanode with high coulombic efficiency and current density. Chem. Phys. Chem. 14:2260-2269. DOI: 10.1002/cphc.201300046

93.Nyanhongo, G.S., Sygmund, C., Ludwig, R., Prasetyo, E.N., Guebitz, G.M. (2013) Synthesis of multifunctional bioresponsive polymers for the management of chronic wounds. J. Biomed. Mat. Res.B: 101:882-891. DOI: 10.1002/jbm.b.32893

92.Kaswurm, V., Hecke, W.V., Kulbe, K.D., Ludwig, R. (2013) Guidelines for the application of NAD(P)H regenerating glucose dehydrogenase in synthetic processes. Adv. Synth. Catal. 355:1709-1714. DOI: 10.1002/adsc.201200959

91.Mate, D.M., Gonzalez-Perez, D., Kittl, R., Ludwig, R., Alcalde, M. (2013) Functional expression of a blood tolerant laccase in Pichia pastoris. BMC Biotechnology, 13:38. DOI: 10.1186/1472-6750-13-38

90.Sygmund, C., Santner, P., Krondorfer, I., Peterbauer, C.K., Alcalde, M., Nyanhongo, G.S., Guebitz, G.M., Ludwig, R. (2013) Semi-rational engineering of cellobiose dehydrogenase for improved hydrogen peroxide production. Microb. Cell Fact. 12:38. DOI: 10.1186/1475-2859-12-38

89.Shao, M., Pöller, S., Sygmund, C., Ludwig, R., Schuhmann, W. (2013) A low-potential glucose biofuel cell anode based on a toluidine blue modified redox polymer and the flavodehydrogenase domain of cellobiose dehydrogenase. Electrochem. Commun. 29:59-62. DOI: 10.1016/j.elecom.2013.01.016

88.Nyanhongo, G.S., Sygmund, C., Ludwig, R., Prasetyo, E.N., Guebitz, G.M. (2013) An antioxidant regenerating system for continuous quenching of free radicals in chronic wounds. Eur. J. Pharmaceut. Biopharmaceut. 83:396-404. DOI: 10.1016/j.ejpb.2012.10.013

87.Salaj-Kosla, U., Scanlon, M.D., Baumeister, T., Zahma, K., Ludwig, R., Conghaile, P.O., MacAodha, D., Leech, D., Magner, E. (2013) Mediated electron transfer of cellobiose dehydrogenase and glucose oxidase at osmium polymer-modified nanoporous gold electrodes. Anal. Bioanal. Chem. 405:3823-3830. DOI: 10.1007/s00216-012-6657-4

86.Ludwig, R., Ortiz, R., Schulz, C., Harreither, W., Sygmund, C., Gorton, L. (2013) Cellobiose dehydrogenase modified electrodes: Advances by materials science and biochemical engineering. Anal. Bioanal. Chem. 405:3637-3658. DOI: 10.1007/s00216-012-6627-x

85.Feifel, S.C., Kapp, A., Ludwig, R., Gorton, L., Lisdat, F. (2013) Electrocatalytically active multi-protein assemblies using nanoscaled building blocks. RSC Advances, 3:3428-3437. DOI:  10.1039/C2RA22819J

84.Pöller, S., Shao, M., Sygmund, C., Ludwig, R., Schuhmann, W. (2013) Low potential biofuel cell anodes based on redox polymers with covalently bound phenothiazine derivatives for wiring flavin adenine dinucleotide-dependent enzymes. Electrochim. Acta, 110:152-158. DOI: 10.1016/j.electacta.2013.02.083

83.Mate, D.M., Gonzalez-Perez, D., Falk, M., Kittl, R., Pita, M., De Lacey, A.L., Ludwig, R., Shleev, S., Alcalde, M. (2013) Blood tolerant laccase by directed evolution. Chemistry and Biology, 20:223-231. DOI: 10.1016/j.chembiol.2013.01.001

82.Shao, M., Nadeem Zafar, M., Sygmund, C., Guschin, D.A., Ludwig, R., Peterbauer, C.K., Schuhmann, W., Gorton, L. (2013) Mutual enhancement of the current density and the coulombic efficiency for a bioanode by entrapping bi-enzymes with Os-complex modified electrodeposition paints. Biosens. Bioelectron. 40:308-314. DOI: 10.1016/j.bios.2012.07.069

81.Flitsch, A., Prasetyo, E.N., Sygmund, C., Ludwig, R., Nyanhongo, G.S., Guebitz, G.M. (2013) Cellulose oxidation and bleaching processes based on recombinant Myriococcum thermophilum cellobiose dehydrogenase. Enz. Microbial Technol. 52:60-67. DOI: 10.1016/j.enzmictec.2012.10.007

80.Tasca, F., Ludwig, R., Gorton, L., Antiochia, R. (2013) Determination of lactose by a novel third generation biosensor based on a cellobiose dehydrogenase and aryl diazonium modified single wall carbon nanotubes electrode. Sensors and Actuators, B: Chemical, 177:64-69. DOI: 10.1016/j.snb.2012.10.114

79.Macaodha, D., O'Conghaile, P., Egan, B., Kavanagh, P., Sygmund, C., Ludwig, R., Leech, D. (2013) Comparison of glucose oxidation by crosslinked redox polymer enzyme electrodes containing carbon nanotubes and glucose oxidising enzymes. Electroanalysis, 25:94-100. DOI: 10.1002/elan.201200536

78.Felice, A.K.G., Sygmund, C., Harreither, W., Kittl, R., Gorton, L., Ludwig, R. (2013) Substrate specificity and interferences of a direct-electron-transfer-based glucose biosensor. J. Diabet. Sci. Technol. 7:669-677. DOI: 10.1177/193229681300700312 

 2012

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77.Ortiz, R., Matsumura, H., Tasca, F., Zahma, K., Samejima, M., Igarashi, K., Ludwig, R., Gorton, L. (2012) Effect of deglycosylation of cellobiose dehydrogenases on the enhancement of direct electron transfer with electrodes. Anal. Chem. 84:10315-10323. DOI: 10.1021/ac3022899

76.Kovacs, G., Ortiz, R., Coman, V., Harreither, W., Popescu, I.C., Ludwig, R., Gorton, L. (2012) Graphite electrodes modified with Neurospora crassa cellobiose dehydrogenase: Comparative electrochemical characterization under direct and mediated electron transfer. Bioelectrochemistry, 88:84-91. DOI: 10.1016/j.bioelechem.2012.06.006

75.Kaswurm, V., Pacher, C., Kulbe, K.D., Ludwig, R. (2012) 2,5-Diketo-gluconic acid reductase from Corynebacterium glutamicum: Characterization of stability, catalytic properties and inhibition mechanism for use in vitamin C synthesis. Process Biochem. 47:2012-2019. DOI: 10.1016/j.procbio.2012.07.014

74.Harreither, W., Felice, A.K.G., Paukner, R., Gorton, L., Ludwig, R., Sygmund, C. (2012) Recombinantly produced cellobiose dehydrogenase from Corynascus thermophilus for glucose biosensors and biofuel cells. Biotechnol. J. 7:1359-1366. DOI: 10.1002/biot.201200049

73.Kittl, R., Kracher, D., Burgstaller, D., Haltrich, D., Ludwig, R. (2012) Production of four Neurospora crassa lytic polysaccharide monooxygenases in Pichia pastoris monitored by a fluorimetric assay. Biotechnol. Biofuels, 5:79. DOI: 10.1186/1754-6834-5-79

72.Ferrandi, E.E., Monti, D., Patel, I., Kittl, R., Haltrich, D., Riva, S., Ludwig, R. (2012) Exploitation of a laccase/Meldola's blue system for NAD+ regeneration in preparative scale hydroxysteroid dehydrogenase-catalyzed oxidations. Adv. Synth. Catal. 354:2821-2828. DOI: 10.1002/adsc.201200429

71.Sarauli, D., Ludwig, R., Haltrich, D., Gorton, L., Lisdat, F. (2012) Investigation of the mediated electron transfer mechanism of cellobiose dehydrogenase at cytochrome c-modified gold electrodes. Bioelectrochem. 87:9-14. DOI: 10.1016/j.bioelechem.2011.07.003

70.Sygmund, C., Kracher, D., Scheiblbrandner, S., Zahma, K., Felice, A.K.G., Harreither, W., Kittl, R., Ludwig, R. (2012) Characterization of the two Neurospora crassa cellobiose dehydrogenases and their connection to oxidative cellulose degradation. Appl. Environ. Microbiol. 78:6161-6171. DOI: 10.1128/AEM.01503-12

69.Matsumura, H., Ortiz, R., Ludwig, R., Igarashi, K., Samejima, M., Gorton, L. (2012) Direct electrochemistry of Phanerochaete chrysosporium cellobiose dehydrogenase covalently attached onto gold nanoparticle modified solid gold electrodes. Langmuir, 28:10925-10933. DOI: 10.1021/la3018858

68.Kittl, R., Gonaus, C., Pillei, C., Haltrich, D., Ludwig, R. (2012) Constitutive expression of Botrytis aclada laccase in Pichia pastoris. Bioengineered, 3:232-235. DOI: 10.4161/bioe.20037

67.Vasilchenko, L.G., Ludwig, R., Yershevich, O.P., Haltrich, D., Rabinovich, M.L. (2012) High-throughput screening for cellobiose dehydrogenases by Prussian Blue in situ formation. Biotechnol. J. 7:919-930. DOI: 10.1002/biot.2011

66.Feifel, S.C., Ludwig, R., Gorton, L., Lisdat, F. (2012) Catalytically active silica nanoparticle-based supramolecular architectures of two proteins - Cellobiose dehydrogenase and cytochrome c on electrodes. Langmuir, 28:9189-9194. DOI: 10.1021/la301290z

65.Zafar, M.N., Safina, G., Ludwig, R., Gorton, L. (2012) Characteristics of third-generation glucose biosensors based on Corynascus thermophilus cellobiose dehydrogenase immobilized on commercially available screen-printed electrodes working under physiological conditions. Anal. Biochem. 425:36-42. DOI: 10.1016/j.ab.2012.02.026

64.Harreither, W., Nicholls, P., Sygmund, C., Gorton, L., Ludwig, R. (2012) Investigation of the pH-dependent electron transfer mechanism of ascomycetous class II cellobiose dehydrogenases on electrodes. Langmuir, 28:6714-6723. DOI: 10.1021/la3005486

63.Kovacs, G., Ortiz, R., Coman, V., Harreither, W., Popescu, I.C., Ludwig, R., Gorton, L. (2012) Influence of SAM structure on direct electron transfer at au electrodes modified with cellobiose dehydrogenase from Neurospora crassa. Revue Roumaine de Chimie, 57:361-368.

62.Stanescu, M.D., Gavrilas, S., Ludwig, R., Haltrich, D., Lozinsky, V.I. (2012) Preparation of immobilized Trametes pubescens laccase on a cryogel-type polymeric carrier and application of the biocatalyst to apple juice phenolic compounds oxidation. Europ. Food Res. Technol. 234:655-662. DOI: 10.1007/s00217-012-1676-0

61.Schulz, C., Ludwig, R., Micheelsen, P.O., Silow, M., Toscano, M.D., Gorton, L. (2012) Enhancement of enzymatic activity and catalytic current of cellobiose dehydrogenase by calcium ions. Electrochem. Commun. 17:71-74. DOI: 10.1016/j.elecom.2012.01.031

60.Zafar, M.N., Beden, N., Leech, D., Sygmund, C., Ludwig, R., Gorton, L. (2012) Characterization of different FAD-dependent glucose dehydrogenases for possible use in glucose-based biosensors and biofuel cells. Anal. Bioanal. Chem. 402:2069-2077. DOI: 10.1007/s00216-011-5650-7

59.Kittl, R., Mueangtoom, K., Gonaus, C., Khazaneh, S.T., Sygmund, C., Haltrich, D., Ludwig, R. (2012) A chloride tolerant laccase from the plant pathogen ascomycete Botrytis aclada expressed at high levels in Pichia pastoris. J. Biotechnol. 157:304-314. DOI: 10.1016/j.jbiotec.2011.11.021

58.Wang, X., Falk, M., Ortiz, R., Matsumura, H., Bobacka, J., Ludwig, R., Bergelin, M., Gorton, L., Shleev, S. (2012) Mediatorless sugar/oxygen enzymatic fuel cells based on gold nanoparticle-modified electrodes. Biosens. Bioelectron. 31:219-225. DOI: 10.1016/j.bios.2011.10.020

57.Zafar, M.N., Wang, X., Sygmund, C., Ludwig, R., Leech, D., Gorton, L. (2012) Electron-transfer studies with a new flavin adenine dinucleotide dependent glucose dehydrogenase and osmium polymers of different redox potentials. Anal. Chem. 84:334-341. DOI: 10.1021/ac202647z

 2011

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56.Sygmund, C., Staudigl, P., Klausberger, M., Pinotsis, N., Djinović-Carugo, K., Gorton, L., Haltrich, D., Ludwig, R. (2011) Heterologous overexpression of Glomerella cingulata FAD-dependent glucose dehydrogenase in Escherichia coli and Pichia pastoris. Microb. Cell Fact. 10:106. DOI: 10.1186/1475-2859-10-1

55.Sygmund, C., Klausberger, M., Felice, A.K., Ludwig, R. (2011) Reduction of quinones and phenoxy radicals by extracellular glucose dehydrogenase from Glomerella cingulata suggests a role in plant pathogenicity, Microbiology, 157:3203-3212. DOI: 10.1099/mic.0.051904-0

54.Uhnáková, B., Ludwig, R., Pěknicová, J., Homolka, L., Lisá, L., Šulc, M., Petříčková, A., Elzeinová, F., Pelantová, H., Monti, D., Křen, V., Haltrich, D., Martínková, L. (2011) Biodegradation of tetrabromobisphenol A by oxidases in basidiomycetous fungi and estrogenic activity of the biotransformation products. Biores.Technol. 102:9409-9415. DOI: 10.1016/j.biortech.2011.07.036

53.Patel, I., Ludwig, R., Haltrich, D., Rosenau, T., Potthast, A. (2011) Studies of the chemoenzymatic modification of cellulosic pulps by the laccase-TEMPO system. Holzforschung, 65:475-481. DOI: 10.1515/hf.2011.035

52.Pricelius, S., Ludwig, R., Lant, N., Haltrich, D., Gübitz, G.M. (2011). In situ-generation of  hydrogen peroxide by carbohydrate oxidase and cellobiose dehydrogenase for bleaching purposes.  Biotechnology J.6:225-230. DOI: 10.1002/biot.201000246

51.Vasilchenko, L.G., Karapetyan, K.N., Yershevich, O.P., Peterbauer, C., Zamocky, M., Ludwig, R., Haltrich, D., Rabinovich, M.L. (2011) Cellobiose dehydrogenase of Chaetomium sp. INBI 2-26(-): homology with cellobiose dehydrogenases of thermophilic fungi and activity towards glucose at neutral pH. Biotechnol. J. 6:538-553. DOI: 10.1002/biot.201000373

50.Tasca, F., Harreither, W., Ludwig, R., Gooding, J., Gorton, L. (2011) Cellobiose dehydrogenase aryl diazonium modified single walled carbon nanotubes: enhanced direct electron transfer through a positively charged surface. Anal. Chem. 83:3042-3049. DOI: 10.1021/ac103250b

49.Harreither, W., Sygmund, C., Augustin, M., Narciso, M., Rabinovich, M.L., Gorton, G., Haltrich, D., Ludwig, R. (2011) Catalytic properties and classification of cellobiose dehydrogenase from ascomycetes:. Appl. Environ. Microbiol. 77:1804-1815. DOI: 10.1128/AEM.02052-10 

48.Van Hecke, W., Haltrich, D., Frahm, B., Brod, H., Dewulf, J., Van Langenhove, H., Ludwig, R. (2011) A biocatalytic cascade reaction sensitive to the gas-liquid interface: modeling and upscaling in a dynamic membrane aeration reactor. J. Mol. Catal. B: Enz. 69:154-161. DOI: 10.1016/j.molcatb.2010.10.004

47.Tasca, F., Zafar, M.N., Harreither, W., Nöll, G. Ludwig, R., Gorton, L. (2011). A third generation glucose biosensor based on cellobiose dehydrogenase from Corynascus thermophilus and single-walled carbon nanotubes. Analyst, 136:2033-2036. DOI: 10.1039/C0AN00311E

 2010

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46.Ludwig, R., Harreither, W., Tasca, F., Gorton, L. (2010) Cellobiose dehydrogenase: a versatile catalyst for electrochemical applications. Chem. Phys. Chem. 11:2674-2697. DOI: 10.1002/cphc.201000216

45.Mueangtoom, K., Kittl, R., Mann, O., Haltrich, D., Ludwig, R. (2010) Low pH dye decolorization with ascomycete Lamprospora wrightii laccase. Biotechnol. J. 5:875-870. DOI: 10.1002/biot.201000120

44.Spadiut, O., Posch, G., Ludwig, R., Haltrich D., Peterbauer, C. (2010) Evaluation of different expression systems for the heterologous expression of pyranose 2-oxidase from Trametes multicolor in E. coli. Microb. Cell. Fact. 9:14. DOI: 10.1186/1475-2859-9-14

43.Esteban, M., Ludwig, R., Gorton, L., Mandler, D. (2010) Direct electron transfer as means for localized deposition of gold nanoparticles, a scanning electrochemical microscopy study (SECM). Chem. Eur. J. 16: 11697-11706.

42.Safina, G., Ludwig, R., Gorton, L. (2010) A simple and sensitive method for lactose detection based on direct electron transfer between immobilised cellobiose dehydrogenase and screen-printed carbon electrodes. Electrochim. Acta, 55:7690-7695. DOI: 10.1016/j.electacta.2009.10.052

41.Coman, V., Ludwig, R., Harreither, W., Haltrich, D., Gorton, L., Ruzgas, T., Shleev, S. (2010)Potentially implantable membrane-, mediator-, cofactor-less glucose/oxygen biofuel cell. Fuel Cells, 10:9-16.

40.Tasca, F., Gorton, L., Kujawa, M., Patel, I., Harreither, W., Peterbauer, C.K., Ludwig. R., Nöll, G. (2010) Increasing the coulombic efficiency of glucose biofuel cell anodes by combination of redox enzymes. Biosens. Bioelect. 25:1710-1716. DOI: 10.1016/j.bios.2009.12.017

 2001-2009

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39.Patel, I., Ludwig, R., Mueangtoom, K., Haltrich, D., Rosenau, T., Potthast, A. (2009) Comparing soluble Trametes pubescens laccase and cross-linked enzyme crystals (CLECs) for enzymatic modification of cellulose. Holzforschung 63:715-720. DOI: 10.1515/HF.2009.073

38.van Hecke, W., Salaheddin, C., Ludwig, R., Dewulf, J., Haltrich, D., Langenhove, H.V. (2009) Biocatalytic cascade oxidation using laccase for pyranose 2-oxidase regeneration. Biores.      Technol. 100:5566-5573. DOI: 10.1016/j.biortech.2009.06.032

37.Tasca, F., Gorton, L., Harreither, W., Haltrich, D., Ludwig, R., Nöll, G. (2009) Comparison between direct and mediated electron transfer for cellobiose dehydrogenase from Phanerochaete sordida. Anal. Chem. 81:2791-2798. DOI: 10.1021/ac900225z

36.Pricelius, S., Ludwig, R., Lant, N., Haltrich, D., Gübitz, G.M. (2009) Substrate specificity of Myriococcum thermophilum cellobiose dehydrogenase on mono-, oligo- and polysaccharides related to in-situ production of H2O2. Appl. Microbiol. Biotechnol. 85:75-83. DOI: 10.1007/s00253-009-2062-0

35.Trashin, S.A., Haltrich, D., Ludwig, R., Gorton, L., Karyakin, A.A. (2009) Improvement of direct bioelectrocatalysis by cellobiose dehydrogenase on screen printed graphite electrodes using polyaniline modification. Bioelectrochem. 76:87-92. DOI: 10.1016/j.bioelechem.2009.06.004

34.Salaheddin C., Spadiut, O., Ludwig, R., Tan, T.-C., Divne, C., Haltrich, D., Peterbauer, C. (2009) Probing active-site residues of pyranose 2-oxidase from Trametes multicolor by semi-rational design. Biotechnol. J. 4:535-543. DOI: 10.1002/biot.200800265

33.Harreither, W., Sygmund, C., Dünhofen, E., Vicuna, R., Haltrich, D., Ludwig, R. (2009) Cellobiose dehydrogenase from the ligninolytic basidiomycete Ceriporiopsis subvermispora. Appl. Environ. Microbiol. 75:2750-2557. DOI: 10.1128/AEM.02320-08

32.Berthiller, F., Hametner, C., Krenn, P., Schweiger, W., Ludwig, R., Adam G., Krska, R., Schuhmacher, R. (2009) Preparation and characterization of the conjugated Fusarium mycotoxins zearalenone-4O-b-D-glucopyranoside, a-zearalenol-4O-b-D-glucopyranoside and b-zearalenol-4O-b-D-glucopyranoside by MS/MS and two-dimensional NMR. Food Additives and Contaminants 26:207-213. DOI: 10.1080/02652030802399034

31.Stoica, L., Dimcheva, N., Ackermann, Y., Karnicka, K., Guschin, D.A., Kulesza, P.J., Rogalski,    J., Haltrich, D., Ludwig, R., Gorton, L., Schuhmann, W. (2009). Membrane-less biofuel cell  based on cellobiose dehydrogenase (anode)/laccase (cathode) wired via specific Os-redox polymers. Fuel Cells 9:53-62. DOI: 10.1002/fuce.200800033

30.Coman, V., Vaz-Dominguez, C., Ludwig, R., Harreither, W., Haltrich, D., Ruzgas, T., Gorton, L., Shleev, S. (2008) A membrane-, mediator-, cofactor-less glucose/oxygen biofuel cell. PCCP        40:6093-6096. DOI: 10.1039/B808859D

29.van Hecke, W., Ludwig, R., Dewulf, J., Haltrich, D., van Langenhove, H. (2008) Green oxidation of renewable carbohydrates: lactobionic acid production as an example. Comm. Agr. Appl. Biol. Sci. 73:9-13.

28.van Hecke, W., Bhagawat, A., Ludwig, R., Dewulf, J., Haltrich D., van Langenhove, H. (2009) Kinetic modelling of a bi-enzymatic system for efficient conversion of lactose to lactobionic acid. Biotechnol. Bioeng. 102:1475-1482. DOI: 10.1002/bit.22165

27.van Hecke, W., Ludwig, R., Dewulf, J., Auly, M., Messiaen, T., Haltrich D., van Langenhove, H. (2009) Bubble-free oxygenation of a bi-enzymatic system: effect on biocatalyst stability. Biotechnol. Bioeng. 102:122-131. DOI: 10.1002/bit.22042

26.Tasca, F., Gorton, L., Harreither, W., Haltrich, D., Ludwig, R., Nöll, G. (2008) Highly efficient and versatile anodes for biofuel cells based on cellobiose dehydrogenase from Myriococcum      thermophilum. J. Phys. Chem. C. 112:13668-13673. DOI: 10.1021/jp805092m

25.Tasca, F., Gorton, L., Harreither, W., Haltrich, D., Ludwig, R., Nöll, G. (2008) Direct electron transfer at cellobiose dehydrogenase modified anodes for biofuel cells. J. Phys. Chem. C. 112:9956-9961. DOI: 10.1021/jp802099p

24.Sukyai, P., Resic, T., Haltrich, D., Ludwig, R. (2008) Comparing soluble and co-immobilized catalysts for 2-ketoaldose production by pyranose 2-oxidase and auxiliary enzymes. J. Biotechnol. 135:281-290. DOI: 10.1016/j.jbiotec.2008.04.002

23.Zámocký, M., Schümann, C., Sygmund, C., O’Callaghan, J., Dobson, A.D.W., Ludwig, R.,  Haltrich, D., Peterbauer, C. (2008) Cloning, sequence analysis and heterologous expression in Pichia pastoris of a gene encoding a thermostable cellobiose dehydrogenase from Myriococcum thermophilum. Prot. Express. Purif. 59:258-265. DOI: 10.1016/j.pep.2008.02.007

22.Maischberger, T., Nguyen, T-H., Sukyai, P., Kittl. R., Riva, S., Ludwig, R., Haltrich, D. (2008) Production of lactose-free galacto-oligosaccharide mixtures: comparison of two cellobiose dehydrogenases for the selective oxidation of lactose to lactobionic acid. Carbohydr. Res. 343:2140-2147. DOI: 10.1016/j.carres.2008.01.040

21.Shleev, S., Wang, Y., Gorbacheva, M., Christenson, A., Haltrich, D., Ludwig, R., Ruzgas, T., Gorton, L. (2008) Direct Heterogeneous Electron Transfer Reactions of Bacillus halodurans Bacterial Blue Multicopper Oxidase. Electroanalysis 20:963-969. DOI: 10.1002/elan.200704116

20.Spadiut, O., Leitner, C., Tien-Chye, T., Ludwig, R., Divne, C., Haltrich, D. (2008) Mutations of   Thr169 affect substrate specificity of pyranose 2-oxidase from Trametes multicolor. Biocatal. Biotransf. 26:120-127. DOI: 10.1080/10242420701789320

19.Krenn, P., Berthiller, F., Schweiger, W., Hametner, C., Ludwig, R., Adam, G., Krska, R.,  Schuhmacher, R. (2007) Production of zearalenone-4-glucoside, a-zearalenol-4-glucoside and ß-zearalenol-4-glucoside. Mycotoxin Res. 23:180-184. DOI: 10.1007/BF02946045

18.Coman, V., Harreither, W., Ludwig, R., Haltrich, D., Gorton, L. (2007) Investigation of electron transfer between cellobiose dehydrogenase from Myriococcum thermophilum and Au electrodes. Chem. Anal. (Warsaw) 52:945-960.

17.Nyanhongo G.S., Gübitz G., Sukyai P., Leitner, C. Haltrich, D., Ludwig R. (2007) Oxidoreductases from Trametes spp. in biotechnology: a wealth of catalytic activity. Food Technol. Biotechnol. 45:250-268

16.Rabinovich, M.L., Vasil’chenko, L.G., Karapetyan, K.N., Shumakovich, G.P., Yershevich, O.P., Ludwig, R., Haltrich, D., Hadar, Y., Kozlov, Y.P., Yaropolov, A.I. (2007) Application of cellulose- based self-assembled tri-enzyme system in a pseudo-reagent-less biosensor for biogenic catecholamine detection. Biotechnol. J. 2:546-558. DOI: 10.1002/biot.200600221

15.Tasca, F., Timur, S., Ludwig, R., Haltrich, D., Volc J., Antiochia R. and Gorton L. (2007) Amperometric biosensors for detection of sugars based on the electrical wiring of different pyranose oxidases and pyranose dehydrogenases with Osmium redox polymer on graphite electrodes. Electroanal. 19:294-302. DOI: 10.1002/elan.200603740

14.Harreither, W., Coman, C., Ludwig, R., Haltrich, D. and Gorton, L. (2007) Investigation of graphite electrodes modified with cellobiose dehydrogenase from the ascomycete Myriococcum thermophilum. Electroanal. 19:172-180. DOI: 10.1002/elan.200603688

13.Stoica, L., Ruzgas, T., Haltrich, D., Ludwig, R. and Gorton, L. (2006) Direct electron transfer – A favourite electron route for cellobiose dehydrogenases from Trametes villosa. Comparison with CDH from Phanerochaete chrysosporium. Langmuir, 22:10801-10806. DOI: 10.1021/la061190f

12.Kujawa, M., Ebner, H., Leitner, C., Hallberg, M.B., Prongjit, M., Sucharitakul, J., Ludwig, R., Rudsander, U., Peterbauer, C., Chaiyen, P., Haltrich, D. and Divne, C. (2006) Structural basis for substrate binding and regioselective oxidation of monosaccharides at C3 by pyranose 2-oxidase. J. Biol. Chem. 281:35104-35115. DOI: 10.1074/jbc.M604718200

11.Stoica, L., Ludwig, R., Haltrich, D. and Gorton, L. (2006) Third-generation biosensor for lactose based on newly discovered cellobiose dehydrogenase. Anal. Chem. 78:393-398. DOI: 10.1021/ac050327o

10.Zámocký, M., Ludwig, R., Peterbauer, C., Hallberg, B. M., Divne, C., Nicholls, P. and Haltrich, D (2006) Cellobiose dehydrogenase – a flavocytochrome from wood-degrading, phytopathogenic and saprotropic fungi. Curr. Prot. Pept. Sci. 7:255-280. DOI: 10.2174/138920306777452367

9.Karapetyan, K.N. Fedorova, T.V., Vasilchenko, L.G., Ludwig, R., Haltrich, D. and Rabinovich, M.L. (2005) Properties of neutral cellobiose dehydrogenase from the ascomycete Chaetomium sp. INBI 2-26(-) in comparison with basidiomycetuous cellobiose dehydrogenases. J. Biotechnol. 121:34-48. DOI: 10.1016/j.jbiotec.2005.06.024

8.Zámocký, M., Hallberg, M., Ludwig, R., Divne, C. and Haltrich, D. (2004) Ancestral gene fusion in cellobiose dehydrogenases reflects a specific evolution of GMC oxidoreductases in fungi. Gene, 338:1-14. DOI: 10.1016/j.gene.2004.04.025

7.Ludwig, R., Ozga, M., Zámocký, M., Peterbauer, C., Kulbe, K. D. and Haltrich, D. (2004) Continuous enzymatic regeneration of electron acceptors used by flavoenzymes: Cellobiose dehydrogenase-catalyzed production of lactobionic acid as an example. Biocatalysis Biotrans. 22:97-104. DOI: 10.1080/10242420410001692787

6.Haltrich, D., Ludwig, R. and Zámocký, M. (2004) Cellobiose dehydrogenase. An extracellular flavocytochrome from the phytopathogenic basidomycete Sclerotium (Athelia) rolfsii. ACS Symp. Ser. 889:271-285.

5.Ludwig, R., Salamon, A., Varga, J., Zámocký, M., Peterbauer, C.K., Kulbe, K.-D. and Haltrich D. (2004) Characterisation of cellobiose dehydrogenases from the white rot fungi Trametes pubescens and Trametes villosa. Appl. Microbiol. Biotechnol. 64:213-222. DOI: 10.1007/s00253-003-1501-6

4.Ludwig, R. and Haltrich, D. (2003) Optimisation of cellobiose dehydrogenase production by the phytopathogenic fungus Sclerotium (Athelia) rolfsii. Appl. Microbiol. Biotechnol. 61:32–39. DOI: 10.1007/s00253-002-1209-z

3.Ludwig, R. and Haltrich, D. (2002) Cellobiose dehydrogenase production by Sclerotium species pathogenic to plant. Lett. Appl. Microbiol. 35:261–266. DOI: 10.1046/j.1472-765X.2002.01170.x

2.Leitner, C., Hess, J., Galhaup, C., Ludwig, R., Nidetzky, B., Kulbe, K.-D. and Haltrich, D. (2002) Purification and characterization of a laccase from the white-rot fungus Trametes multicolor. Appl. Biochem. Biotechnol. 98–100:497–507. DOI: 10.1385/ABAB:98-100:1-9:497

1.Baminger, U., Ludwig, R., Galhaup, C., Leitner, C., Kulbe, K.-D. and Haltrich, D. (2001) Continuous enzymatic regeneration of redox mediators used in biotransformation reactions employing flavoproteins. J. Mol. Catal. B: Enzymatic 11:541–550. DOI: 10.1016/S1381-1177(00)00034-5